Previous gestational diabetes, a population known to be at high risk of multimetabolic syndrome 24 ; . A special cohort of women n 124 ; with previous gestational diabetes were examined 8 years after they delivered mean age at follow-up, 38.1 6.3 years ; . Of these subjects, 78 had diabetes or impaired glucose tolerance, and 38 had hypertension at follow-up; mean waist circumference was 86.9 15.0 cm, mean WHR was 0.81 0.06, and mean BMI was 26.8 6.0 kg m2. We were looking for the relationship of the above-mentioned three anthropometric parameters to current hypertension blood pressure 160 95 mmHg, signs of hypertension on eye fundi, or therapy with antihypertensive medication ; and glucose intolerance therapy with blood glucoselowering medication or an abnormal result of a 75-g OGTT according to the World Health Organization's criteria ; . In multiple linear regression models, all three variables showed statistically significant associations with systolic blood pressure sBP ; [standardized regression coefficient] was 0.323 for waist circumference, 0.375 for WHR, and 0.298 for BMI, with P 0.01, adjusted for age and HbA1c ; . Because fasting blood glucose levels were not available in insulintreated patients, HbA1c was used as a marker of current carbohydrate metabolic status. When similar regression models were applied, only BMI showed a statistically significant relationship with HbA1c BMI 0.279, P 0.02; waist circumference 0.186, P 0.12; and WHR 0.148, P 0.22 ; , adjusted for age and sBP Using the cut points of the three . anthropometric parameters suggested by Okosun et al. 1 ; waist circumference, 80.0 cm; WHR, 0.80; and BMI, 25.0 ; , we found none to have a statistically significant association with diabetes, although BMI seemed to be related to it odds ratio [OR] 2.17 [95% CI 0.96 4.81] ; . However, all three were associated with current hypertension according to the Mantel-Haenszel 2 test adjusted for age and diabetes OR 7.30 [95% CI 2.0328.93] for waist circumference, 3.30 [1.179.43] for WHR, and 6.03 [2.2416.56] for BMI ; . Furthermore, we examined the relationship of prepregnancy BMI ppBMI ; attributed to index pregnancy using the median as the cut point [25.2 kg m2] ; to hypertension excluding those with prepregnancy hypertension ; and diabetes at follow-up. Subjects with ppBMI above.
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Transition. The changes that have taken place and are still going on in the socio-economic life of the country are conducive to higher rates of increase in the prevalence of smoking, especially among women and adolescents. Societal attitudes toward smoking in women are changing. Until recently, society had a certain opinion of smoking: it was viewed as normal among men, whereas smoking in women would arouse negative attitudes with the majority of society. Therefore, many smoking women tended to hide their habit of smoking, also doing so during such surveys. Owing to the socio-economic changes in recent years, the attitude toward smoking in women is becoming more liberal. This promotes smoking among women and more openness in answering the question on smoking. Undoubtedly, the data on the high prevalence of smoking among women obtained in the survey indicate that there is a need to further monitor this parameter, and to co-ordinate action by health institutions and the public opinion to prevent this harmful habit from spreading in the population, especially among women.
TABLE 1. Descriptive characteristics of 150 men, aged 19 40 yr control group ; , and of 792 men, aged 50 85 yr, in whom the subsequent analyses were performed, because medicines.
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The problem is a hearing problem you've got, Mr. Minister. You can't hear. You're insensitive. You're not . you know to get up here and say that the four corners of the health care in Saskatchewan came out of the CUPE Canadian Union of Public Employees ; magazine, is just to try and derail the issue of facing up to health care. Those four corner posts of health care in Saskatchewan were around before CUPE was around, Mr. Minister. The pioneers of this province engineered those pillars and the manifestation of those ideas about health care - came out with hospitalization, pre-cancer treatment, a medical care plan, dental plan, prescription drug plan. That was the manifestation of the four corner posts of health care in Saskatchewan. And you attempt to divert that with the nonsense of saying that the critic got the idea out of the CUPE magazine, Mr. Minister. Just be honest with yourself, Mr. Minister. That's all I'm asking. Hon. Mr. McLeod: Well the only comment I'll make, and I think if you go back to what I said about the CUPE magazine . I'll just leave it quickly. But I was just going through and pointing out to the public and to all the members, frankly, that as I read through this, I was just reading and I could almost literally follow the member's speech, going through this. So I'll just tell you that that was one of the sources. But I would say to you, Mr. Chairman, that the things that the member tends to make like of, a couple of things that he makes light of And, you know, I accept the source from which they come. He makes light of the fact that we are talking about the technology that will be afforded with the technology of the plastic card, and so on, as it relates to the payment for drugs and the potential applications of that kind of technology for several things in this sector. Those are forward-looking things and we don't apologize for that. We don't apologize for looking at what technology can bring to the administrative side of health care. If any one of us would think for a moment - and I invite you all to do that - technology has been very, very rapid. The advancement of technology has been very, very rapid in the medical science area, in the treatment area of the health care sector, and the use of technology in the administrative side of health care has not been very rapid at all. And one should ask the question: why is that? And it's a very difficult question to answer because the administrative side of this very large enterprise we call the health care sector is a very large administrative . very large bureaucracy and all the rest of it, and it goes around the piece. So there's no reason in the world that we should not look for the best technology as it relates to the administrative side of health care and the delivery of that health care to our citizens. And the second one is the commission. The member, as well, talked a little bit about the commission. And I just say to him that those two things, the card and the commission, both of which you tend to just sort of dismiss and say it's some kind of a plot, or whatever, that you like to do . And like I said to your colleague, I recognize what this forum is about and I recognize what it's like to be in opposition and what it is to government. And I know the member does, as well, having sat on both sides of the House, as I have. I'll just say to you that both of those things, the card and the technology and what that might afford to us, and the commission, are both forward looking and they're the kinds of things, the kind of initiatives that we need and that will be widely regarded by the public of this province when they come to understand how well they both will serve us. I just will say that and I will stand upon that and make no apology at all for attempting always to be forward looking in some of these areas and prozac.
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MOLECULAR AND FUNCTIONAL CHARACTERIZATION OF ZEBRAFISH PepT2. T. Verri, G. Kottra1, A. Romano, M. Maffia, H. Daniel1 and C. Storelli. Laboratory of General Physiology, Department of Biological and Environmental Science and Technology, University of Lecce, via Provinciale per Monteroni, Lecce, Italy; 1Molecular Nutrition Unit, Institute of Nutritional Science, Technical University of Munich, Hochfeldweg 2, Freising-Weihenstephan, Germany. J. Physiol. Biochem., 60 2 ; , 124, 2004. Cellular uptake of di- and tripeptides is mediated by integral membrane transport proteins belonging to the Solute Carrier 15 SLC15 ; family. Members of this family have been described in bacteria, fungi, plants, insects, nematodes, birds and mammals. However, information in lower vertebrates are still limited. Among teleost fish, the cyprinid zebrafish Danio rerio ; has emerged as a model organism for experimental biology, vertebrate embryology, developmental genetics and toxicology and is acquiring growing importance in regulatory and integrative physiology. Aims: Molecular and functional characterization of zebrafish PepT1 has been achieved, contributing new insights into the molecular structure and function of the vertebrate low affinity peptide transporters Verri et al., FEBS Lett. 549: 115, 2003 ; . The present study was performed to characterize the high affinity peptide transporter PepT2 of zebrafish. Methods and Results: An EST cDNA GenBank acc. no. AW153469 ; corresponding to zebrafish PepT2 was obtained from the IMAGE Consortium and completed by inserting a stretch of 75 missing nucleotides in the coding sequence to obtain a fully functional clone of 3238 bp. Zebrafish PepT2 orf was 2160 bp long and encoded for a protein of 719 amino acids with at least 12 potential transmembrane domains. Comparison of zebrafish PepT2 with related amino acid sequences from other vertebrates revealed higher similarity to PepT2 5160% ; than to PepT1 47-50% ; transporters. As assessed by RT-PCR, zebrafish PepT2 was mainly expressed in kidney, brain and, interestingly, intestine. Electrophysiological analysis after cRNA injection in Xenopus laevis oocytes suggested that zebrafish PepT2 is a highaffinity transport system, exhibiting a K0.5 value of 505 M at -160 mV and 133 M at -100 mV n 16 ; at 7.5. Also, maximal current Imax 22926 nA ; was observed at pH 7.5, decreasing to 894% at pH 8.5 and to 5719% at pH 6.5 all values at -160 mV; n 11 ; . Conclusions: Basic molecular and functional characterization of zebrafish PepT2 has been achieved. Our findings will contribute to study fish peptide transporters in a well-established genetic background and might help to elucidate the evolutionary and functional relationships among peptide transporters in vertebrates and
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SCREENING FOR CERVICAL DYSPLASIA: PRELIMINARY RESULTS OF A SURVEY IN SLE PATIENTS Sasha Bernatsky, Ann Clarke, Glinda Cooper, Chris Mill, Rosalind Ramsey-Goldman , Chris Pineau Montreal General Hospital, Quebec, NIH, Durham, N. Carolina, Northwestern University, Chicago, Ill, Montreal General Hospital, Quebec ; Recent work has suggested that women with systemic lupus erythematosus SLE ; have an increased prevalence of cervical dysplasia and atypia on Pap testing. However, no studies to date have examined the frequency of Pap test screening in women with SLE, compared to the general population or to established guidelines. Objectives: To determine the frequency of Pap test screening in an SLE sample, and to determine if the frequency is higher or lower than that of the general population. Methods: Consecutive patients N 95 ; seen in the Montreal General Hospital lupus clinic were surveyed regarding health screening practices. Reported practices of Pap testing among women with SLE were compared to Quebec population figures. Results: Only one patient declined the survey, based on inability to read or speak English or French. Of the 94 respondents, 84 were females. Of these 84 women, sixteen 19.0% ; were aged less than thirty, 40 47.6% ; were 30-49, and the remainder 28, 33.3% ; were 50 or older. Three women reported a past history of cervical dysplasia 3.6% of the sample ; . Only one of these three had had a Pap test in the last 12 months. Altogether, only 39.3% 95% CI 29.5, 50.0 ; of the 84 female SLE respondents reported having a Pap test in the preceding 12 months. This compares with a Quebec population rate for reported yearly Pap tests of 52.0% 51.7, 52.3% ; . In younger women, for whom recent guidelines emphasize yearly Pap tests, only 6 of 16 SLE subjects aged less than 30 had Pap tests done in the past 12 months 37.5%, 95% CI 18.5, 62.4 ; . This compares with a general population rate of 55.9% 52.9, 58.9 ; for similarly aged women in Quebec. Conclusions: Our sample of women with SLE was less likely than the general population to have had yearly Pap testing. Younger women with SLE in particular may be under-screened. Care should be taken that recommendations regarding Pap testing are not neglected in SLE patients, particularly those with a past history of dysplasia and
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The Drugs listed in the left-hand column below should be the only drugs used in the Pre-hospital and Referring Hospital Drug fields. Please be sure that you copy values exactly as listed below spelling, punctuation, and case ; . All values listed will fit in the NTRACS choice field 30 characters ; . Note that [sp] indicates that you should space between the characters, do not type [sp] , but rather just press the space bar once for every time [sp] appears. You do not have to enter the entire list in your program, you may enter only those that you use. You may also list the AKA in the Description Field if you want. If you need to add any other values, please first contact Annette O'Dell or Sharon Schiro to have the values added to the approved list. Drug - Generic Abciximab Acetaminophen Adenosine Albuterol Alprazolam Aminocaproic[sp] acid Aminophylline Amiodarone Amyl[sp] Nitrate Antibiotics Aspirin Atenolol Atropine Blood Bretylium Bumetanide Calcium[sp] chloride Calcium[sp] gluconate Cefazolin[sp] sodium Celecoxib Charcoal Cimetidine Cisatracurium[sp] besylate Clonidine Clopidogrel Colloid[sp] solution Crystalloid[sp] solution Cyanide[sp] poison[sp] kit D10 D10W D25 D50 D50W D5-1 2NS D5-1 4NS D5LR D5NS D5W Dexamethasone Diazepam Digoxin AKA Reopro Tylenol Adenocard Airet, Proventil, Ventolin, Volmax, Salbutamol Xanax Amicar Phyllocontin, Truphylline Cordarone Ampicillan, Ancef, Keflex, Penicillan Tenormin Homatropine, Scopolamine.
249. Shapiro GS, Klinger NM, Ekholm BP, Colice GL. Comparable bronchodilation with hydrofluoroalkane134a HFA ; albuterol and chlorofluorocarbons-11 12 CFC ; albuterol in children with asthma. J Asthma 2000; 37: 66775. Colice GL, Klinger NM, Ekholm BP, Dockhorn RJ. Proventil HFA prevents exercise-induced bronchoconstriction in children. J Asthma 1999; 36: 6716. Lumry W, Noveck R, Weinstein S, Barnhart F, VanderMeer A, Murray A, et al. Switching from Ventolin CFC to Ventolin HFA is well tolerated and effective in patients with asthma. Ann Allergy Asthma Immunol 2001; 86: 297303. Pearlman DS, Kane RE, Banerji D. Comparative dose-ranging study of triamcinolone acetonide inhalation aerosol using propellants hydrofluoroalkane 134a or P-12 in children with chronic asthma. Curr Ther Research Clin Exp 1999; 60: 595606. Farmer IS, Middle M, Savic J, Perri VL, Herdman MJ. Therapeutic equivalence of inhaled beclomethasone dipropionate with CFC and nonCFC HFA 134a ; propellants both delivered via the Easi-Breathe inhaler for the treatment of paediatric asthma. Respir Med 2000; 94: 5763. Furukawa C, Atkinson D, Forster TJ, Nazzario K, Simpson B, Uryniak T, et al. Controlled trial of two formulations of cromolyn sodium in the treatment of asthmatic patients 12 years of age. Chest 1999; 116: 6572. Leynadier F, Herman D, Vervloet D, Andre C. Specific immunotherapy with a standardized latex extract versus placebo in allergic healthcare workers. J Allergy Clin Immunol 2000; 106: 58590. Hughes DA, Woodcock A, Walley T. Review of therapeutically equivalent alternatives to short acting beta 2 ; adrenoceptor agonists delivered via chlorofluorocarbon-containing inhalers. Thorax 1999; 54: 108792. Jonasson G, Carlsen KH, Sodal A, Jonasson C, Mowinckel P. Patient compliance in a clinical trial with inhaled budesonide in children with mild asthma. Eur Respir J 1999; 14: 1504. Jonasson G, Carlsen KH, Mowinckel P. Asthma drug adherence in a long term clinical trial. Arch Dis Child 2000; 83: 3303. Mahajan P, Okamoto L. Patient satisfaction with the Diskhaler and the Diskus inhaler, a new multidose powder delivery system for the treatment of asthma. Clin Ther 1997; 19: 112634. Van der Palen J, Klein JJ, Schildkamp AM. Comparison of a new multidose powder inhaler Diskus Accuhaler ; and the Turbuhaler regarding preference and ease of use. J Asthma 1998; 35: 14752 and ritalin.
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Delivered Endowment Lecture on 'Comparative Indian Literature: Trends and Future Directions' at the Professor Ulahannan Mapilla Memorial Endowment Lecture, Centre for Oriental Studies, Post-Graduate Centre, B.P. College, Cenganacherry. Presented a paper on 'Ethical and Moral Code of Conduct and the Vacanas' at the National Conference on Twelfth Century Sharana Revolution and the Indian Constitution', organized by the Akhila Bharata Sharana Sahtya Parishat, Delhi. Presented a paper on 'Kuvempu Novels as Knowledge Systems' at the National Seminar on 'Centenary of Kuvempul. Delhi : Delhi Karnataka Sangha. Presented a paper on 'Interpreting Early Kannada Translations' at the National Seminar on 'Translation, Interpretation and Culture: Issues and Trends', organized by the Indian Institute of Technology, Bombay. Presented a paper on 'The Changing Identities in a Diaspora Community: The IndoGuyanese Community' at the National Seminar on 'Challenge before me as a Writer and Identity Crisis of Language Communities as Reflected in Indian Literature', organized by the Department of MIL & L5. Presented a paper on 'Some Aspects of Early Kannada Translations' at the National Seminar on 'Research at Crossroads', organized by the Department of MIL & L5. Professor Jayanti Chattopadhyay: Presented a paper on 'Poetry and Science' at the National Seminar, organized by the Burdhwan University, West Bengal, and also delivered lectures as a Visiting Fellow, in the Department of Bengali, Burdhwan University, West Bengal. Dr. G. Rajagopal: Presented a paper entitled 'Nayakkars of Tamilandu - A quest for Identity' at the National Seminar on 'Identity Crisis of Language Communities as Reflected in Indian Literature', organized by the Department of MIL & LS and CIIL, Mysore, held at Delhi. Dr. Ravi Prakash Tekchandani: Presented paper on 'Bhartiya Sanvidhan Mein Sindhi Hit' at the 11th International Sindhi Conference held in London U.K., organized by the Sindhi Association, U.K. Presided over one session in Sindhi Teachers and Students Conference in Byawar. Conducted as co-ordinator of the Seminar on 'Media in Indian Literature' in Rajkot. Participated as discussant, 'Sindhi Drama and Puppet', of the Seminar organized by NCPSL. Participated in the preparation of Urdu-Hindi Dictionary, organized by the National Council for promotion of Urdu language, Ministry of H.R.D. 78 and rohypnol.
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In another letter to Lancet, doctors from Kelo University Hospital confirmed the somewhat unexpected domination of nicotinic signs and symptoms over the muscarinic ones only one patient had mild bradycardia, 50 beats per minute ; and questioned usefulness of treatment of mild cases of sarin intoxication with atropine sulphate eye drops, because of atropine-induced photophobia and poor focusing [25]. The physicians from St. Luke's International Hospital in Tokyo reported 641 victims of the subway sarin poisoning seen at the hospital, with 111 of them hospitalised [26, 27]. This number included five patients admitted with cardiopulmonary or respiratory arrest with marked miosis and extremely low serum cholinesterase values. Two of them died, while the rest of them recovered completely. Another 106 patients including four pregnant women ; had symptoms of mild to moderate exposure. The rest of victims 530 ; had only mild symptoms and were released after 6 hours of observation. Major signs and symptoms were: miosis, headache, dyspnoea, nausea, ocular pain, blurred vision, vomiting, coughing, muscle weakness and agitation. Almost all of them had miosis, headache, blurred vision and visual darkness. Although all these symptoms disappeared within two weeks, psychological problems associated with post-traumatic stress disorder persisted longer. Besides, 20% of the medical staff showed some sort of physical abnormality due to secondary contamination. The ophthalmologists from the Japanese Red Cross Medical Centre treated 96 people intoxicated with sarin gas on March 20, 1995 [28]. Twenty-one of them were passengers from the subway train cars which contained the source of sarin gas generation, while the rest of them were passengers from different cars of the same train, or from different trains. The duration of their exposure to vapours of sarin ranged from several to 20 minutes. The most frequent pathological findings were conjunctival injection 91.7% ; and miosis, associated with a sensation of darkness 81.3% ; . Miosis was particularly severe and accompanied with complete loss of accommodation in patients who were in the same car with the source of nerve gas generation. Despite iv or im treatment with atropine sulphate 0.5-3.0 mg, recovery of normal pupillary diameter required 3-21 days. Ocular pain was the third most frequently 58.3% ; found symptom and it was successfully treated with 0.5% tropicamide eye drops. About 37.5% of these victims complained of subjective accommodation impairment. Intraocular pressure was 11.6 mm Hg 2 hours after exposure to toxic vapours, but it increased to 14.6 mm Hg after the resolution of miosis. Only five patients had a decreased plasma cholinesterase activity.
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Medication and personal items - It is best to bring a supply of any personal medication you take on a regular basis, in sufficient quantity to last through your stay. However, if an unexpected need arises, most medications are available readily in Tana. Many antibiotics and prescription drugs are available in local drug stores without a prescription. These include fairly new antibiotics, etc., but they tend to be sold under the proprietary names of European pharmaceutical companies. The pharmacists are very helpful though. Medical books - Thanks to the enthusiastic response from our volunteers and supporters, we have a fairly decent collection of pathology text and reference books in the laboratory. If you have any reference books or textbooks you are willing to donate, especially if they are newer editions, please check with Dr. Richard Lynch to see if they are appropriate. We are trying to avoid too many duplicate copies. If you have any French language pathology book, they can definitely use them. Laboratory supplies - We suggest that you bring along a box of gloves for your own use and some blades for grossing in. Most of the laboratory supplies and reagents were purchased in the U. S. and shipped through SALFA's support facility in Minneapolis. If you can get your vendor to donate some reagents or supplies e.g. paraffin, cassettes, slides, coverslips, microtome blades, stains, etc. ; , they will be much appreciated. If you are bringing in a substantial lot of supplies, please let Dr. Victor Lee know so he can make up an official Certificate of Donation for you. This may avoid any holdup when you clear customs in Madagascar. Claire Stolee, a former missionary with SALFA, formed a support organization called SALFA Overseas Assistance in Minnesota. He makes periodic container shipments to SALFA in Madagascar and has a lot of experience clearing these supplies through customs. If you want to ship supply items through him, please contact Dr. Richard Lynch, our Project Director in charge of shipping see front cover.
The values of calcium: magnesium ratio in drinking water. Significance on health D Diaconu, O Voroniuc, V Nastase, E Nechifor, O Nechifor Iai, Romania ; Effects of chronic l-name and magnesium upon arterial blood pressure and in vitro vascular reactivity in rats M Hogas, DN Serban, IL Serban, S Tucaliuc, M Nechifor Iasi, Romania ; Biophysical and clinical evaluation in pre-term delivery treatment with magnesium and hexoprenalin D Urzica, D Dorohoi, M Lazarescu, R Lazarescu Iasi, Romania ; Neuroprotective properties of 6-hydroxy-flavanone in two murine models of epilepsy: magnesium deficiency-dependent audiogenic seizure and pentylenetetrazole tests P Maurois, N Pags , P Bac, N Becker, J Durlach, J Vamecq Paris, Strasbourg, Lille , France ; Neuroprotective potential of chronic rapeseed oil diet in magnesium-deficient P6 mice, evaluated by audiogenic seizure test P Maurois , N Pags, J Vamecq, G Agnani, P Bac., J Durlach, B Delplanque Paris, Strasbourg, Lille , France ; Magnesium status in dyalised chronic kidney diseases D Zalutchi , LM Deac , M Gherman, M Butan Cluj-NapocaRomania ; The modifications of plasma, erythrocyte and urinary magnesium in the diabetic patients comparing with the non-diabetic ones A Onaca, I Vlad, M Onaca, L Faur, A Erdei, R Chis Oradea , Romania ; The correlation insulinoresistance M Onaca , I Vlad , A Onaca, L Faur, A Erdei, R Chis Oradea.
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